Article: Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats.
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Yoshimura N; Bennett NE; Hayashi Y; Ogawa T; Nishizawa O; Chancellor MB; de Groat WC; Seki S
J. Neurosci., 2006
Table 3.
K+ and Na+ current characteristics of bladder afferent neurons with TTX-resistant spikes from vehicle-treated and NGF-treated rats
|
Vehicle |
NGF (2 weeks) |
K+ currents
|
|
|
No. of cells |
15 |
20 |
Input capacitance (pF) |
30.8 ± 1.7 |
42.5 ± 2.7** |
KA conductance (at 0 mV)
|
|
|
Max (nS) |
33.6 ± 4.4 |
21.9 ± 2.8* |
Normalized (nS/pF) |
1.09 ± 0.16 |
0.52 ± 0.07** |
KDR conductance (at 20 mV)
|
|
|
Max (nS) |
39.9 ± 3.8 |
49.9 ± 3.3 |
Normalized (nS/pF) |
1.33 ± 0.13 |
1.19 ± 0.09 |
Na+ currents
|
|
|
No. of cells |
15 |
20 |
Input capacitance (pF) |
30.1 ± 1.6 |
43.1 ± 2.6** |
TTX-R Na+ conductance (at 10 mV)
|
|
|
Max (nS) |
69.5 ± 3.6 |
97.4 ± 3.9* |
Normalized (nS/pF) |
2.31 ± 0.12 |
2.26 ± 0.11 |
TTX-S Na+ conductance (at 10 mV)
|
|
|
Max (nS) |
42.3 ± 4.1 |
53.1 ± 3.5 |
Normalized (nS/pF) |
1.41 ± 0.13 |
1.23 ± 0.10 |
Inferred neuron-electrophysiology data values
Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |